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Research Technology Platforms

Through our academic partners, we have access to state-of-the-art research infrastructure. Our ability to combine and apply these technologies across our themes of Diagnosis, Therapeutics and eHealth makes us distinctive and excellent.

Technology Platform I (Genomics, bioinformatics and computational biology)

  • Next-generation sequencing platforms
    • DNA, WGS, exome
  • RNA and epigenetics(e.g. chromatin architecture)
  • Proteomics core (Mass spectrometry)
  • Bioinformatics and systems biology core
  • Compute and storage facilities for datasets

Technology Platform II (Preclinical disease phenotyping)

  • iPSC lines, in vitro modelling and gene editing
  • Molecular and cellular imaging, including high content image analysis
  • Electrophysiology (Slice and single cell analysis)
  • Pre-clinical in vivo phenotyping
    • mouse models for MND/ALS and epilepsies
    • digital and telemetric quantitative EEG 
    • behaviour assays and brain function monitoring
  • Brain imaging (7T rodent MRI)
  • Retinal imaging (Heidelberg OCT and Fundus Fluorescein angiography)

Technology Platform III (Sensor Development)

  • Companion diagnostics
  • High-speed electrochemistry
  • Super resolution fluorescence microscopy
  • Sensor system prototyping - screen printing, 3D printing and micromilling

Technology Platform IV (eHealth enabled patient support)

  • National electronic patient records system
  • Integration of genomic and phenotypic information
  • Patient portal infrastructure (Patient Reported Outcome Measurements)
  • Integration of wearables
  • Clinical analytics (e.g. disease risk, treatment response)

Technology Platform V (Clinical research)

  • Clinical infrastructure for trials
  • Patient registers
  • Biobanking and biosample collection (>2,500 DNA, brain tissue and biofluids)
  • Advanced neurophysiology and brain function (fMRI, EEG)
  • Dynamic contrast enhanced MRI (DCE-MRI)
  • Transcranial magnetic stimulation
  • Large patient datasets of structural MRI