|Areas of expertise:||MicroRNA|
Janosch is a Postdoctoral Researcher in the Physiology & Medical Physics Department at RCSI as well as in FutureNeuro. He is funded through a Marie Skłodowska-Curie Individual Fellowship. He has a Diplom in Biology from the University of Cologne, Germany and a PhD in Clinical Neurosciences from the University of Cambridge, UK. Prior to joining FutureNeuro, Janosch worked as a Research Associate at University College London, UK with Prof Dmitri Rusakov, using super-resolution microscopy to image astrocyte processes surrounding excitatory synapses. His research in FutureNeuro focuses on elucidating local translation in astrocyte processes in the healthy brain and in epilepsy. Janosch uses super-resolution microscopy to visualize microRNAs and locally produced proteins in astrocytes. As a novel strategy that could benefit patients with drug-resistant, refractory epilepsy, he targets candidate microRNAs to influence astrocyte morphology, and increase local translation of neurotransmitter and ion channels in astrocytic processes. This allows the clearing of excess glutamate and potassium from the synaptic cleft and hence prevents synchronous neuronal discharges that generate seizures.