AMPK-regulated miRNA-210-3p is activated during ischaemic neuronal injury and modulates PI3K-p70S6K signalling

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Shona Pfeiffer, Anna Tomašcová, Uta Mamrak, Stefan J. Haunsberger, Niamh M. C. Connolly, Alexa Resler Heiko Düssmann Petronela Weisová, Elisabeth Jirström, Beatrice D’Orsi, Gang Chen , Mattia Cremona, Bryan T. Hennessy, Nikolaus Plesnila, Jochen H. M. Prehn

Progressive neuronal injury following ischaemic stroke is associated with glutamate‐induced depolarization, energetic stress and activation of AMP‐activated protein kinase (AMPK). We here identify a molecular signature associated with neuronal AMPK activation, as a critical regulator of cellular response to energetic stress following ischaemia.

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Posted on

29/03/2021