ATP and adenosine—Two players in the control of seizures and epilepsy development


Edward Beamer, Manvitha Kuchukulla, Detlev Boison, Tobias Engel 

Despite continuous advances in understanding the underlying pathogenesis of hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains a clinical challenge. Over one third of patients remain resistant to current pharmacological interventions. Moreover, even when effective in suppressing seizures, current medications are merely symptomatic without significantly altering the course of the disease.

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