IgG 1 pan-neurofascin antibodies identify a severe yet treatable neuropathy with a high mortality


Janev Fehmi Alexander J Davies Jon Walters Timothy Lavin Ryan Keh Alexander M Rossor Tudor Munteanu Norman Delanty Rhys Roberts Dirk Bäumer Graham Lennox Simon Rinaldi 

We aimed to define the clinical and serological characteristics of pan-neurofascin antibody-positive patients. We tested serum from patients with suspected immune-mediated neuropathies for antibodies directed against nodal/paranodal protein antigens using a live cell-based assay and solid-phase platform. The clinical and serological characteristics of antibody-positive and seronegative patients were then compared. Sera positive for pan-neurofascin were also tested against live myelinated human stem cell-derived sensory neurons for antibody binding. See more here. 



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