Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice


Edward Beamer James Morgan Mariana Alves Aida Menéndez Méndez Gareth Morris Béla Zimmer Giorgia Conte Laura de Diego-Garcia Cristina Alarcón-Vila Nico Ka Yiu Ng Stephen Madden Francesco Calzaferri Cristobal de Los Rios Antonio G Garcia Michael Hamacher Klaus DinkelPablo Pelegrin David C Henshall Annette Nicke Tobias Engel 

Refractory status epilepticus is a clinical emergency associated with high mortality and morbidity. Increasing evidence suggests neuroinflammation contributes to the development of drug-refractoriness during status epilepticus. The aim of the present study was to determine the contribution of the ATP-gated P2X7 receptor (P2X7R), previously linked to both inflammation and increased hyperexcitability, to drug-refractory status epilepticus and its therapeutic potential.

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