Role of Common Genetic Variants for Drug-Resistance to Specific Anti-Seizure Medications

Stefan Wolking , Ciarán Campbell , Caragh Stapleton , Mark McCormack , Norman Delanty , Chantal Depondt , Michael R Johnson , Bobby P C Koeleman, Roland Krause , Wolfram S Kunz , Anthony G Marson , Josemir W Sander , Graeme J Sills , Pasquale Striano , Federico Zara , Sanjay M Sisodiya , Gianpiero L Cavalleri , Holger Lerche 

Resistance to anti-seizure medications (ASMs) presents a significant hurdle in the treatment of people with epilepsy. Genetic markers for resistance to individual ASMs could support clinicians to make better-informed choices for their patients. In this study, we aimed to elucidate whether the response to individual ASMs was associated with common genetic variation.

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