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In my PhD project, I will determine the effects of cannabinoids, particularly cannabidiol (CBD), on microRNA expression in epilepsy. MicroRNAs are small non-coding RNA molecules that can regulate the gene expression. CBD is known to have anti-epileptic activity, but the underlying molecular mechanisms are still unknown. I will characterise the effects of CBD on microRNA expression and investigate whether the anti-epileptic effects are dependent on the regulation of microRNAs. At the same time, I will also examine if microRNAs are important regulators of the body’s own cannabinoid system (endocannabinoid system) and its signalling pathway.

Research Areas