Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides


Edward Beamer Mary Isabel O’Dea Aisling A Garvey Jonathon Smith Aida Menéndez-Méndez Lynne Kelly Andreea Pavel Sean Quinlan Mariana AlvesEva M Jimenez-Mateos Faming Tian Eugene Dempsey Nicholas Dale Deirdre M Murray Geraldine B Boylan Eleanor J Molloy Tobias Engel 


Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted to clinical diagnosis with no molecular tests available. Purines including adenosine are released during brain injury such as hypoxia and are also present in biofluids. Whether blood purine changes can be used to diagnose NE has not been investigated to date. See more here. 

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