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Coproducing health and well-being in partnership with patients, families, and healthcare providers: A qualitative study exploring the role of an epilepsy patient portal

Zita McCrea, Kevin Power, Rachel Kiersey, Maire White, Annette Breen, Sinead Murphy, Laura Healy, Hugh Kearney, Brendan Dunleavy Sean O’Donoghue, Veronica Lambert, Norman Delanty, Colin Doherty, Mary Fitzsimons.  ...

Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse

Morgan J, Alves M, Conte G, Menéndez-Méndez A, de Diego-Garcia L, de Leo G, Beamer E, Smith J, Nicke A, Engel T. https://doi.org/10.1007/s12264-020-00573-9 Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the...

Analysis of the aetiology of epilepsy in 3,216 adult patients attending a tertiary referral center enabled by an electronic patient record

Delaney S, Fitzsimons M, White M, Power K, O’ Donoghue S, Kilbride R, Widdess-Walsh P, El Naggar H, Delanty N. https://doi.org/10.1016/j.seizure.2020.08.005 Purpose The aim of this study was to review the causes of the epilepsies in our institution, an adult...

Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice

Almeida Silva LF, Reschke CR, Nguyen NT, Langa E, Sanz-Rodriguez A, Gerbatin RR, Temp FR, de Freitas ML, Conroy RM, Brennan GP, Engel T, Henshall DC. https://doi.org/10.1186/s13041-020-00653-x MicroRNAs perform important roles in the post-transcriptional regulation of...

Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy

Brennan GP, Bauer S, Engel T, Jimenez-Mateos EM, Del Gallo F, Hill TDM, Connolly NMC, Costard LS, Neubert V, Salvetti B, Sanz-Rodriguez A, Heiland M, Mamad O, Brindley E, Norwood B, Batool A, Raoof R, El-Naggar H, Reschke CR, Delanty N, Prehn JHM, Fabene P, Mooney C,...
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